帕金森病与骨骼系统相关性的研究进展

Research progress on the relationship between Parkinson’s disease and the skeletal system

关键词:  帕金森病  骨质疏松症  骨代谢  病理生理机制

Key words:  Parkinson’s disease (PD)  osteoporosis  bone metabolism  interdisciplinary dialogue  pathophysiological mechanisms

摘要:

帕金森病（Parkinson’s disease，PD）是一种慢性神经退行性疾病，其特征包括运动和非运动症状，严重 限制患者的日常活动。近年来的多项分子、生物学和遗传学研究表明，PD的易感基因在大脑以外的外周器官和组 织均有表达，在骨细胞中也有表达。因此，这些研究合理地促使人们思考“帕金森病可能是一种全身性疾病”的观 点。目前大量证据表明，帕金森病患者更容易发生骨质疏松和骨折，与年龄相匹配的对照组相比，帕金森病患者的 骨折风险显著增加。该文阐述了帕金森病与骨骼系统相关性的研究进展，旨在为帕金森病患者骨骼健康的评估、 管理、治疗和潜在研究方向提供参考。

Abstract:

Parkinson’s disease (PD) is a chronic neurodegenerative disorder marked by both motor and non-motor symptoms, significantly impeding daily activities. Recent molecular, biological, and genetic investigations reveal the expression of PD susceptibility genes in peripheral organs and tissues, including bone cells, suggesting that PD may be classified as a systemic ailment. Evidence increasingly supports that individuals with PD are at heightened risk for osteoporosis and fractures, displaying a substantially greater incidence of fractures compared to age-matched controls. This article elaborates on the research progress of the correlation between Parkinson’s disease and the skeletal system, aiming to provide a reference for the assessment, management, treatment, and potential research directions of bone health in Parkinson’s disease patients.