| 摘要: |
| 乳腺癌是一种异质性较高的肿瘤，染色体扩增是驱动肿瘤细胞异质性的主要原因之一。1q21 区域的扩增是
人类乳腺癌中最常见的基因组拷贝数变化事件，该区域扩增型乳腺癌患者的疾病进展、耐药性和死亡的风险均增加。与
1q21 扩增相关的染色体畸变会导致该区域内致癌基因的表达失调，进而诱发乳腺癌转移、化学耐药及肿瘤复发等。该文
对 1q21 扩增型乳腺癌相关的致癌基因及其功能研究进行综述，以期为开发和优化针对 1q21 扩增型乳腺癌的诊疗提供
科学依据。 |
| 关键词: 乳腺癌 1q21 扩增 致癌基因 |
| DOI： |
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| 基金项目:国家级大学生创新创业训练计划项目（202210571022），2022 年广东省科技创新战略专项资金（攀登计划专项资金） （pdjh2022b0221），广东省基础与应用基础研究粤莞联合基金地区培育项目（2023A1515140057），松山湖材料实验室开放 课题基金资助（2023SLABFN21） |
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| Advances on oncogenes of 1q21 amplified breast cancer |
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| Abstract: |
| Breast cancer is a highly heterogeneous tumor, and chromosome amplification is one of the main factors driving
the heterogeneity of tumor cells. Amplification of the 1q21 region is the most common event of genome copy number change in
human breast cancer, and patients with breast cancer with this region amplification are at increased risk of disease progression,
drug resistance, and death. Chromosomal aberrations associated with the expansion of 1q21 can lead to the dysregulation of
oncogene expression in this region, thereby inducing breast cancer metastasis, chemical resistance, and tumor recurrence. In
this review, the oncogenes related to 1q21 amplified breast cancer and their functions were summarized, in order to provide
scientific basis for the development and optimization of the diagnosis and treatment of 1q21 amplified breast cancer. |
| Key words: breast cancer 1q21 amplification oncogene |