| 摘要: |
| 肝纤维化（HF）由多种细胞、介质和信号通路调控，最终导致细胞外基质和胶原过度沉积的复杂病理过程。
蛋白质翻译后修饰（PTMs）是DNA转录成mRNA并进一步翻译成蛋白质后，底物与功能基团的一种化学修饰。HF的过
程经历了广泛的PTMs。该文就蛋白质磷酸化和亚硝基化修饰对HF的作用进行综述。 |
| 关键词: 肝纤维化 蛋白质翻译后修饰 磷酸化 亚硝基化 |
| DOI： |
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| 基金项目:东莞市社会发展科技项目重点项目（20221800905692） |
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| Role of protein translational modifications in hepatic fibrosis |
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| () |
| Abstract: |
| Hepatic fibrosis (HF) is complex pathological process that is regulated by a variety of cells, mediators, and
signaling pathways, and leads to excessive deposition of extracellular matrix and collagens. Protein translational modifications
(PTMs) are chemical modifications of substrates and functional groups after DNA is transcribed into mRNA and further
translated into proteins. The HF process undergoes extensive PTMs. This paper reviews the role of protein phosphorylation and
nitrosylation in HF. |
| Key words: hepatic fibrosis PTMs phosphorylation nitrosylation |
