| 摘要: |
| 目的 分析 8-羟基脱氧鸟苷（8-OHdG）的研究现状和热点。方法 收集中国知网 1996-2022 年 8-OHdG相
关文献，使用CiteSpace软件进行可视化分析。结果 共纳入文献 652 篇，研究热点主要有氧化应激、氧化损伤和活性氧
等。8-OHdG主要与冠心病、阿尔次海默症、糖尿病等相关。结论 目前大多数研究仅局限于将 8-OHdG当作一个检测指
标，外源性 8-OHdG有望治疗氧化损伤相关疾病。 |
| 关键词: 8-羟基脱氧鸟苷 CiteSpace 可视化分析 |
| DOI： |
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| 基金项目:广东省自然科学基金(2021B1515140012, 2023A1515010083)，东莞市社会发展科技项目(20211800905342), 广东医科大学 大学生创新创业训练项目(GDMU2022031, GDMU2022047),省级和国家级大学生创新创业训练计划项目(202210571008, S202210571075) |
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| Visual analysis of 8-hydroxy-2'-deoxyguanosine related research progress based on CiteSpace |
| WU Jia-nan1 , LIANG Ying-shi1 , HU Yang-hui1 , YANG Yu-jia1 , CHEN Zi-lin1 , HU Mian-da1 , XIE Dong-xia1 , ZENG Yu1 , ZHANG Wan-qing1 ,WANG Yu-ni1 , CAI Xiao-lin1 , DU Yi-kuan2*, YANG Chun1* |
| (1. Dongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, Guangdong Medical University, Dongguan 523059, China; 2. The Tenth Affiliated Hospital of Southern Medical University, Dongguan 523059, China) |
| Abstract: |
| Objective To analyze the research status and hotspots of 8-hydroxy-2'-deoxyguanosine (8-OHdG) using
CiteSpace. Methods 8-OHdG-related literature between 1996 and 2022 was retrieved from CNKI database, and analyzed
by visualization analysis with CiteSpace software. Results A total of 652 articles were included, of which oxidative stress,
oxidative damage and reactive oxygen species were the research hotspots. 8-OHdG was closely related to coronary heart
disease, Alzheimer’s disease, and diabetes. Conclusion 8-OHdG serves as a testing index in most of the current studies. The
exogenous 8-OHdG is expected to treat oxidative damage-related diseases. |
| Key words: 8-hydroxy-2'-deoxyguanosine CiteSpace visual analysis |
