摘要: |
PAMM(Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes)是一种氧化还原调节蛋白,在脂肪组
织中高表达,具有广泛的生物学作用,是脊髓损伤的标志物及某些肿瘤治疗的候选靶点。该文就PAMM的生物学功能及
其临床应用前景作一综述。 |
关键词: PAMM 脂肪因子 抗氧化 |
DOI: |
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基金项目:广东省自然科学基金(2021A1515012236),广东医科大学附属医院“临床医学+”科技合作项目(CLP2021B011),广东医 科大学学科建设类“临床+基础”专项项目(4SG23287G) |
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Biological function and potential application of adipocytokine PAMM |
YANG Xin-xin1,2, HE Yue-jing3 , MA Jia-yi1,2, YE Xuan-xuan1,2, SHI Yu-cang4 , XU Ming-feng5 , LIANG Jie4 , WU Zhiyuan4 , SUN Xue-rong1* |
(1. Institute of Aging Research, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan 523808, China; 2. The Second Clinical Medical School, Guangdong Medical University, Dongguan 523808, China; 3. Clinical Laboratory, Dongguan Eighth People’s Hospital, Dongguan 523321, China; 4. Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China; 5. Department of Physiology, Guangdong Medical University, Zhanjiang 524023, China) |
Abstract: |
PAMM (Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes) is a redox-regulated protein that is
highly expressed in adipose tissue, and has various biological roles. It can serve as a biomarker for spinal cord injury and a
candidate target for certain tumors. This paper reviews the biological function and potential application of PAMM. |
Key words: PAMM adipocytokine antioxidation |