| 摘要: |
| 糖尿病性心肌病（DCM）是糖尿病患者持续性高血糖、高胰岛素血症导致的严重心血管并发症之一，
死亡率高。沉默信息调节因子3（SIRT3）是一种烟酰胺腺嘌呤二核苷酸（NAD +）依赖性脱乙酰酶蛋白，通过多种信
号通路参与调节氧化应激、线粒体功能、细胞凋亡等病理生理过程，在 DCM 中发挥保护作用。该文阐述了 SIRT3
在DCM中，特别是心脏线粒体代谢和功能调节中的研究进展。 |
| 关键词: 糖尿病 糖尿病性心肌病 沉默信息调节因子3 心脏线粒体 |
| DOI：10.20227/j.cnki.2096-3610.2025.02.013 |
|
| 基金项目:国家自然科学基金（81670252） |
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| Research advances on the role of Sirtuin 3 in diabetic cardiomyopathy |
| FENG Taoshan1,2 , MA Guoda2 , CHEN Xiaoming1* |
| (1. Department of Endocrinology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524023, China 2. Maternal and Child Researh Institute, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan 528300, China) |
| Abstract: |
| Diabetic cardiomyopathy (DCM) is a severe cardiovascular complication resulting from persistent
hyperglycemia and hyperinsulinemia in diabetic patients, showing a high mortality rate. Sirtuin 3 (SIRT3) is a
nicotinamide adenine dinucleotide (NAD + ) -dependent deacetylase that participates in various signaling pathways to
regulate oxidative stress, mitochondrial function, apoptosis, and other pathophysiological processes, thereby exerting a
protective effect in DCM. This review provides an overview of the latest research progress on SIRT3, focusing
particularly on its involvement in regulating cardiac mitochondrial metabolism and function in the context of DCM. |
| Key words: diabetes diabetic cardiomyopathy Sirtuin 3 cardiac mitochondria |
