| 摘要: |
| 目的 观察阿替普酶联合银杏二萜内酯葡胺（GDLM）对磁共振弥散加权成像（MRI DWI）与液体衰减反
转恢复成像（FLAIR）失配急性缺血性脑卒中（AIS）的疗效。方法 94 例MRI-DWI/FLAIR失配AIS患者随机接受阿替
普酶（对照组）或阿替普酶联合GDLM（观察组）治疗 2 周，比较两组疗效、不良反应、血清炎症因子（IL-6、IL-8、IL-1β、hsCRP）水平、血液流变学指标。结果 观察组疗效明显优于对照组（P<0.05），但不良反应差异无统计学意义（P>0.05）。
两组治疗后IL-6、IL-8、hs-CRP和IL-1β水平及血液流变学指标均明显低于治疗前，其中观察组更显著（P<0.01 或 0.05）。
结论 阿替普酶联合GDLM治疗MRI DWI-FLAIR失配AIS疗效优于单用阿替普酶治疗者，显著降低炎症因子水平和改
善血液流变学指标。 |
| 关键词: MRI DWI-FLAIR失配 急性缺血性脑卒中 阿替普酶 银杏二萜内酯葡胺 |
| DOI： |
|
| 基金项目:广东省重点领域研发计划项目(2020B1111100009) |
|
| Clinical observation of alteplase and ginkgo diterpene lactone meglumine on acute ischemic stroke with MRI DWI /FLAIR mismatch |
|
| () |
| Abstract: |
| Objective To observe the efficacy of combined alteplase and ginkgo diterpene lactone meglumine (GDLM) in
acute ischemic stroke (AIS) with magnetic resonance imaging diffusion weighted imaging/fluid attenuated inversion recovery
(MRI DWI/FLAIR) mismatch. Methods Ninety-four AIS patients with MRI DWI/FLAIR mismatch were randomly treated
with alteplase (control group) or alteplase and GDLM (observation group) for 2 weeks. Clinical efficacy, serum inflammatory
factors (IL-6, IL-8, IL-1β, and hs-CRP), hemorheological indicators, and adverse reactions were compared between 2 groups.
Results The curative effect was better in observation group than in control group (P<0.05), but no significant difference
of adverse reactions was noted between 2 groups (P>0.05). Levels of IL-6, IL-8, hs-CRP and IL-1β and hemorheological
parameters were lower after therapy in both groups, especially in observation group (P<0.01 or 0.05). Conclusion Clinical
efficacy of combined alteplase and GDLM is superior to that of alteplase in AIS patients with MRI DWI/FLAIR mismatched
by reducing inflammatory cytokines and improving hemorheological indicators. |
| Key words: MRI DWI/FLAIR mismatch acute ischemic stroke alteplase ginkgo diterpene lactone meglumine |