铁蛋白、尿酸、同型半胱氨酸、超敏C反应蛋白对原发性高血压患者颈动脉内膜中层厚度增厚的预测价值

Predictive value of ferritin, uric acid, homocysteine, and hypersensitive C-reactive protein for carotid intima-media thickening in primary hypertension

关键词:  铁蛋白  尿酸  同型半胱氨酸  超敏C反应蛋白  原发性高血压  颈动脉内膜中层厚度

Key words:  ferritin  uric acid  homocysteine  hypersensitivity C-reactive protein  primary hypertension  carotid artery intima-media thickness

摘要:

目的 探讨铁蛋白、尿酸、同型半胱氨酸（Hcy）、超敏C反应蛋白（hs-CRP）对原发性高血压患者颈动脉内膜中层厚度（CIMT）增厚的预测价值。方法 106例原发性高血压患者分为CIMT增厚组（55例）和正常组（51例），比较两组铁蛋白、尿酸、Hcy、hs-CRP水平，采用logistic回归分析，并以ROC曲线评价CIMT增厚的预测价值。结果 增厚组的铁蛋白、尿酸、Hcy、hs-CRP水平均明显高于正常组（P<0.01）。logistic回归分析显示铁蛋白、尿酸、Hcy、hs-CRP均是CIMT增厚的独立危险因素（P<0.05）。铁蛋白、尿酸、Hcy、hs-CRP单独检测的AUC分别为0.735、0.802、0.818、0.778,4项指标联合检测的AUC为0.939(P<0.01)。结论 铁蛋白、尿酸、Hcy、hs-CRP在CIMT增厚预测中具有一定价值，但4种指标联合检测的预测效能最高。

Abstract:

Objective To investigate the predictive value of ferritin, uric acid, homocysteine (Hcy), and hypersensitive C-reactive protein (hs-CRP) for carotid intima-media thickening (CIMT) in primary hypertension. Methods A total of 106 patients with primary hypertension were divided into thickening group (55 cases) and normal group (51 cases). Ferritin, uric acid, Hcy, and hs-CRP levels were compared between 2 groups and analyzed Logistic regression analysis. Their predictive value for CIMT was evaluated using ROC curve. Results Ferritin, uric acid, Hcy, and hs-CRP levels were higher in thickening group than in normal group (P<0.01). Logistic regression analysis showed that they were independent risk factors for CIMT (P<0.05). The AUC of ferritin, uric acid, Hcy, hs-CRP, and their combination were 0.735, 0.802, 0.818, 0.778, and 0.939 (P<0.01), respectively. Conclusion There may be some predictive value of ferritin, uric acid, Hcy, and hs-CRP for CIMT in primary hypertension, with the highest of their combined detection.