| 摘要: |
| 急性髓系白血病（AML）是一种源于造血干细胞的血液恶性肿瘤，具有治疗难度大、预后差等特点。表观遗
传学在白血病的发生、发展中起着重要作用。组蛋白甲基化修饰相关基因和酶作为AML治疗靶点的研究取得了较大进
展。该文就组蛋白H3 赖氨酸甲基转移酶在AML中的研究进展进行综述。 |
| 关键词: 急性髓系白血病 表观遗传学 组蛋白赖氨酸甲基转移酶 |
| DOI： |
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| 基金项目:国家自然科学基金项目 (81703266)，广东省自然科学基金项目（2015A030310532），广东医科大学学科建设项目（4SG23003G） |
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| Advances on histone lysine methyltransferase in acute myeloid leukemia |
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| Abstract: |
| Acute myeloid leukemia (AML) is a hematologic malignancy derived from hematopoietic stem cells, with
treatment difficulty and poor prognosis. Epigenetics plays an important role in the development and progression of leukemia.
Histone methylation modification-associated genes and enzymes as therapeutic targets for AML have made great progress. This
article briefly reviews the recent research progress of histone H3 lysine methyltransferase in AML. |
| Key words: acute myeloid leukemia epigenetics histone lysine methyltransferase |