| 摘要: |
| 目的 分析糖尿病视网膜病变（DR）患者血清肿瘤坏死因子（TNF-α）水平及其意义。方法 检测 115 例
DR（DR组）、117 例 2 型糖尿病（DM组）、121 例单纯白内障（对照组）患者血清TNF-α和生化指标水平。结果 DR组和
DM组血清TNF-α水平高于对照组，其中DR组最高（P<0.01 或 0.05）。DR组血清TNF-α与肌酐、尿素氮、尿酸、收缩压呈
正相关，而与肾小球滤过率、高密度脂蛋白胆固醇呈负相关（P<0.01 或 0.05）。ROC曲线分析显示，TNF-α曲线下面积为
0.611。结论 DR患者血清TNF-α升高与肾损伤指标密切相关。 |
| 关键词: 糖尿病视网膜病变 肿瘤坏死因子-α 肾功能 |
| DOI： |
|
| 基金项目:深圳市自然科学基金面上项目（JCYJ20210324113808023） |
|
| Significance of serum TNF-α levels in patients with diabetic retinopathy |
| WANG Li-yu1 , SUN Hong-yan2 , WANG Jing2 , ZHAO Hui-pan2 , ZHENG Xiu-jin1 , WANG Jun2 , LIU Li-lian1 , YANG Ming-ming2 , LIAO Hai-lan1,3* |
| ((1. Guangdong Medical University, Zhanjiang 524023, China; 2. Shenzhen People’s Hospital, Shenzhen 518000, China; 3. Longgang District People’s Hospital, Shenzhen 518172, China) |
| Abstract: |
| Objective To analyze the significance of serum TNF-α levels in patients with diabetic retinopathy (DR).
Methods Serum levels of TNF-α and biochemical indexes were determined in 115 DR, 117 type 2 diabetes mellitus (DM),
and 121 simple cataract (control group) patients. Results Serum TNF-α levels were higher in DR and DM groups than in
control group, especially in DR group (P<0.05). In DR group, serum TNF-α concentrations were positively correlated with
creatinine, blood urea nitrogen, uric acid, and systolic blood pressure, and negatively with eGFR and HDL-C (P<0.01 or
0.05). ROC curve analysis showed that the area under the curve of TNF-α was 0.611. Conclusion Serum TNF-α levels are
associated with renal injury indicators in DR patients. |
| Key words: diabetic retinopathy tumor necrosis factor-α renal function |
