LncRNA调控巨噬细胞参与脓毒症引起的急性肺损伤的研究进展

Research progress on the involvement of long non-coding RNAs in the treatment of spesis-induced

摘要:

急性肺损伤是脓毒症患者最常见的并发症之一，其发病机制极其复杂，临床疗效尚不理想。长链非编 码RNA作为参与脓毒症发展的关键调节因子而备受关注。因此，挖掘潜在的长链非编码RNA基因靶点对于进一 步研究脓毒症导致的急性肺损伤的治疗及改善预后具有重要意义。本文通过系统综述长链非编码RNA对巨噬细 胞的调控关系，阐明了长链非编码RNA在治疗急性肺损伤中的各种重要作用机制和不同信号通路，包括肺泡巨噬 细胞极化、自噬、细胞焦亡等作用机制和 LncRNA/miRNA/MyD88/NF-κB 轴、LncRNA/p65/NF-κB 轴等不同信号通 路，为临床探寻治疗急性肺损伤新靶点和新的治疗途径提供参考。

Abstract:

Acute lung injury, a frequent complication in septic patients, is marked by complex pathogenesis and poor clinical outcomes.. Long non-coding RNA, recognized as a key regulator in sepsis development, has garnered significant attention. Thus, exploring potential long non-coding RNA gene targets holds great significance for further research on the treatment and prognosis of sepsis - induced acute lung injury. In this review, we clarify the mechanisms of long non - coding RNAs in treating acute lung injury by systematically reviewing their regulation of macrophages, including the mechanisms of action such as alveolar macrophage polarization, autophagy, and pyroptosis, as well as different signaling pathways such as the lncRNA/miRNA/MyD88/NF- κB axis and the LncRNA/p65/NF- κB axis, in order to offer references for exploring new clinical targets and treatments.