Abstract:The cGAS-STING signaling pathway, a critical regulator of the innate immune system, has recently been identified as a core driver of age-related inflammation and functional decline. Furthermore, it has been demonstrated to be involved in multiple senescence-associated disease processes. This review summarizes the research progress of the cGAS-STING signaling pathway as an influencing factor in the regulation of cellular senescence and its biological functions in aging-related diseases, and further analyzes the role of cGAS-STING in regulating diverse aging-related cellular functions, including inflammation, tumorigenesis, mitochondrial dysfunction, DNA damage, as well as the biological dysfunctions related to the aging-related diseases. Furthermore, the review sums up the clinical significance and potential of cGAS-STING targeted therapy for aging-related diseases, alongside the challenges encountered. The development of cGAS-STING antagonists or agonists, may provide novel strategies for targeting the cGAS-STING pathway in the treatment of aging-related diseases.
