沉默信息调节因子3在糖尿病性心肌病中的研究进展

Research advances on the role of Sirtuin 3 in diabetic cardiomyopathy

摘要:

糖尿病性心肌病（DCM）是糖尿病患者持续性高血糖、高胰岛素血症导致的严重心血管并发症之一， 死亡率高。沉默信息调节因子3（SIRT3）是一种烟酰胺腺嘌呤二核苷酸（NAD +）依赖性脱乙酰酶蛋白，通过多种信 号通路参与调节氧化应激、线粒体功能、细胞凋亡等病理生理过程，在 DCM 中发挥保护作用。该文阐述了 SIRT3 在DCM中，特别是心脏线粒体代谢和功能调节中的研究进展。

Abstract:

Diabetic cardiomyopathy (DCM) is a severe cardiovascular complication resulting from persistent hyperglycemia and hyperinsulinemia in diabetic patients, showing a high mortality rate. Sirtuin 3 (SIRT3) is a nicotinamide adenine dinucleotide (NAD + ) -dependent deacetylase that participates in various signaling pathways to regulate oxidative stress, mitochondrial function, apoptosis, and other pathophysiological processes, thereby exerting a protective effect in DCM. This review provides an overview of the latest research progress on SIRT3, focusing particularly on its involvement in regulating cardiac mitochondrial metabolism and function in the context of DCM.