The incidence of allergic diseases is increasing year by year， which not only results in a decrease in the quality of life for allergic patients but also causes enormous social and economic burdens on the country. Drugs， being one of the main sources of allergens， are an important cause of life-threatening hypersensi‐ tivity reactions. Correct diagnosis of drug hypersensitivity reactions （DHRs） is crucial for both allergic patients and healthcare providers， as it determines whether to maintain the existing first-line treatment. The current diag‐ nosis for DHRs relies on the detailed clinical history， combined with the results of in vivo and/or in vitro tests. However， the currently available diagnositic methods for DHRs have many limitations， such as complex and time-consuming procedures， the need for well-trained professionals， a lack of standardized drugs， and stan‐ dardized operating procedures for in vivo and in vitro tests， all of which hinder the accurate diagnosis of DHRs. The review will provide an overview of the currently available diagnostic methods for DHRs in clinical practice and their existing problems， subsequently point out future research directions based on these issues.
