基于 2005―2018年 NHANES 数据库探讨膳食炎症与抑郁症的关联及其中睡眠障碍的中介作用

The association of dietary inflammation and depression and the mediating role of sleep disorders basing on the NHANES 2005-2018 database

摘要:

目的 基于美国国家营养与健康调查（NHANES）数据库2005－2018年的数据，对膳食炎症与抑郁症 发病风险的关联进行分析，拟阐明膳食炎症对抑郁症发病风险的影响。方法 纳入 19 763 名研究对象，使用 logistic回归模型分析膳食炎症指数与抑郁症发病风险的关联及膳食炎性和睡眠障碍对抑郁症的交互效应，同时 评价 3者间的关联强度。结果 调整了年龄、性别、种族、身体质量指数、总能量摄入、饮酒情况、吸烟情况和身体 活动变量后，膳食炎症人群（OR = 1.55，95%CI = 1.37 ~ 1.76，P <0.001）和睡眠障碍人群（OR = 4.88，95%CI = 4.40 ~ 5.43， P <0.001）的抑郁风险均上升，促炎膳食与睡眠障碍之间存在相乘交互作用（OR = 1.29，95%CI = 1.03 ~ 1.62，P < 0.001）。膳食炎症和睡眠障碍兼备人群的抑郁症发病风险为无任一因素人群的7.75倍，睡眠障碍的中介效应显著 （β=0.64，95%CI = 0.54 ~ 0.74，P <0.001）。结论 膳食炎症人群患抑郁症的风险上升，睡眠障碍在其中存在显著的 中介效应。

Abstract:

Objective This research utilizes data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2005 to 2018 to investigate the association of dietary inflammation and sleep disorders with depression. Methods The study encompassed 19,763 qualified participants. Logistic regression models were employed to assess the association of dietary inflammation and depression, among which the mediating function of sleep disorder was analyzed. Data were managed and interpreted using IBM SPSS 25.0 and R 4.3.2 software. Results When adjusting for various factors such as age, gender, race, BMI, total energy consumption, alcohol use, smoking habits, and physical exercise, the risk of depression in the pro-inflammatory diet exposure group is higher (OR = 1.55, 95%CI = 1.37-1.76, P< 0.001). In group with sleep disorders, the depression risk is also obviously higher (OR = 4.88, 95%CI = 4.40-5.43, P< 0.001). The risk of developing into depression when exposed to both pro-inflammatory diet and sleep disorders is 7.75 times as to the group with neither exposure. Sleep disorders have mediated the relationship between dietary inflammation and depression (β=0.64, 95%CI = 0.54-0.74, P<0.001). Conclusion People following a proinflammatory diet face an increased risk of developing into depression, and sleep disorders act as a significant mediator in the relationship between dietary inflammation and depression.