Abstract:Objective To solve the current situation and influencing factors of the public’s demand for medical science popularization in China and to provide reference for medical science popularization workers. Methods Literature analysis and expert discussion were used to form the questionnaire of public Medical Science Popularization needs. The questionnaire consists of three parts: demographic information, the public's demand for medical science popularization, and the cognition of medical science popularization. From October to November 2022, 8,272 volunteers were selected nationwide according to the population proportion in eastern, central, western, and northeastern China. Statistical analysis was performed using the statistical description, chi-square test, and binary logistic regression. Results A total of 7, 212 valid questionnaires were collected (87.2%, 7212/8272); the public's highest demand for medical science popularization content was for first aid skills (45.6%, 3290/7212), and the lowest was for medical guidance (30.1%, 2170/7212); the public's highest demand for types of medical science popularization materials was for those with both text and images (57.2%, 4127/7212), and the lowest was for audiovisual materials (38.2%, 2756/7212); the public's highest demand for forms of medical science popularization was for medical science popularization lectures (58.2%, 4196/7212), and the lowest was for medical science popularization exhibitions (41.3%, 2975/7212); the public’s highest demand for channels of medical science popularization was for news apps (46.2%, 3335/7212), and the lowest was for libraries (23.4%, 1689/7212). Logistic regression analysis shows that gender, occupation and marriage have an impact on the demand for medical science popularization content. Gender, occupation, education level, and region have influence on the demand of medical science popularization types. Education level and occupation have influence on the demand of medical popular science form. Region, health status and household registration had influence on the demand for medical science popularization channels (P<0.05). Conclusion The Chinese public shows high demand for medical science popularization, showing a multi-level demand trend. According to different demographic characteristics, utilize existing resources to optimize the medical science communication strategy and realize the optimal communication effect with specific channel characteristics.