抗蛇毒血清过敏反应的研究进展

Research progress of allergic reactions to antivenoms

摘要:

抗蛇毒血清作为毒蛇咬伤的特效药物，在治疗上具有不可替代的临床价值，但其异种蛋白的本质不可避免 地存在着较高的致敏原性，如发生过敏性休克，将对患者的生命安全造成极大威胁。为了提升临床医生对抗蛇毒血清过 敏反应的重视，探寻更合理的解决方案，该文对抗蛇毒血清过敏反应的发病机制、临床表现与治疗策略进行综述。 关键词：毒蛇咬伤；抗蛇毒血清；过敏反应；血清病

Abstract:

Antivenom, as a specific drug for snakebite, has irreplaceable clinical value in treatment. However, its heterologous protein nature inevitably results in high allergenicity. If anaphylactic shock occurs, it will cause great threat to the life safety of patients. In order to enhance the attention of clinicians to antivenin anaphylaxis and explore a more optimal solution, this paper reviews the mechanism, clinical manifestations and treatment strategies of antivenin anaphylaxis by analyzing recent research results and combining with clinical practice.