预处理方法提高外泌体治疗骨关节炎疗效的研究进展

Advances in pretreatment methods to improve the efficacy of exosomes in the treatment of osteoarthritis

摘要:

骨关节炎（Osteoarthritis，OA）是一种严重危害人类健康的慢性关节病，其主要特点是关节软骨的进行性破 坏。但因其自身软骨修复能力有限，至今仍缺乏有效的治疗手段。细胞旁分泌的外泌体(Exosomes，Exo)，可参与多种细 胞活动，对OA具有较好的疗效，然而单独使用天然外泌体治疗OA，面临着器官靶向性差、半衰期短、疗效不佳等问题。 合理的预处理方式可增强外泌体的靶向、稳定及体内半衰期，从而达到治疗OA的目的。该文通过对提高外泌体OA疗效 的预处理方法进行综述，以期为临床应用外泌体治疗OA提供参考。

Abstract:

Osteoarthritis (OA) is a chronic joint disease that seriously jeopardizes human health , primarily characterized by progressive degradation of articular cartilage. However, there is still a lack of effective treatment due to its limited ability to repair cartilage. Paracellularly secreted exosomes , which can participate in a variety of cellular activities, have good therapeutic efficacy in OA. However, the use of natural exosomes alone in the treatment of OA faces problems such as poor joint targeting, short half-life, and poor therapeutic efficacy. A rational pretreatment approach can enhance the targeting, stabilization and in vivo half-life of exosomes for the treatment of OA. In this paper, we review the pre-treatment strategies aimed at enhancing the efficacy of exosomes for OA, in order to provide a scientific basis for the clinical application of exosomes in the treatment of OA.