多胺代谢在精神分裂症中的研究进展

Progress of polyamine metabolism in pathogenesis of schizophrenia

摘要:

多胺代谢在中枢神经系统和其他器官的多种细胞功能中发挥重要作用。越来越多研究表明多胺代谢与精神 分裂症（schizophrenia，SCZ）的病理变化密切相关。在SCZ患者和该疾病的动物模型中，已经证实了多胺以及其前体、衍 生物、代谢酶和相关基因表达的变化。该文就多胺代谢在SCZ中的研究进展进行综述，以期为靶向多胺代谢的SCZ治疗 提供新的思路。

关键词:多胺代谢;精神分裂症

Abstract:

Polyamine metabolism plays an important role in a variety of cellular functions in the central nervous system and other organs. More and more studies have shown that polyamine metabolism is closely related to the pathological changes of schizophrenia. In patients with schizophrenia and in animal models of the disease, it has been confirmed that there are changes in the polyamines, their precursors, derivatives, metabolic enzymes and expression of related genes. This article reviews the research progress of polyamine metabolism in schizophrenia, in order to provide a new idea for schizophrenia treatment targeting polyamine metabolism.

Key words:polyamine metabolism; schizophrenia