139例大血管性急性缺血性脑卒中患者卒中后抑郁程度及危险因素分析

Severity and risk factors of depression following acute ischemic stroke with large vessel occlusion

摘要:

目的 了解大血管性急性缺血性脑卒中（AIS-LVO）后抑郁程度及危险因素。方法 分析139例AIS-LVO患者中AIS-LVO后抑郁发病率及程度，采用多因素logistic回归分析其危险因素。结果 64例（46.0%）患者发生抑郁，其中轻、中和重度分别占29.7%、46.9%和23.4%。入院时美国国立卫生研究院卒中量表（NIHSS）评分和超敏C反应蛋白（hs-CRP）水平、基底节或额叶病变是抑郁的独立危险因素（P<0.01或0.05）。结论 AIS-LVO后抑郁以轻中度为主。入院时NIHSS评分和hs-CRP水平增高、基底节或额叶病变的AIS-LVO患者更易发生抑郁。

Abstract:

Objective To analyze the severity and risk factors of depression following acute ischemic stroke with large vessel occlusion (AIS-LVO). Methods The incidence and severity of depression were analyzed in 139 AIS-LVO patients. The risk factors for depression were evaluated by multivariate logistic regression analysis. Results Depression occurred in 64 (46.0%) cases, with 29.7% of mild, 46.9% of moderate and 23.4% of severe depression. NIHSS and hypersensitive C-reactive protein (hs-CRP) on admission, and basal ganglia or frontal lobe lesions were independent risk factors for depression (P<0.01 or 0.05). Conclusion The depression following AIS-LVO is commonly mild and moderate. High NIHSS and hs-CRP levels on admission, and basal ganglia or frontal lobe lesions are more prone to develop depression in AIS-LVO patients.