铁蛋白、尿酸、同型半胱氨酸、超敏C反应蛋白对原发性高血压患者颈动脉内膜中层厚度增厚的预测价值
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湛江市科技计划项目(2021B01383)


Predictive value of ferritin, uric acid, homocysteine, and hypersensitive C-reactive protein for carotid intima-media thickening in primary hypertension
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    摘要:

    目的 探讨铁蛋白、尿酸、同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)对原发性高血压患者颈动脉内膜中层厚度(CIMT)增厚的预测价值。方法 106例原发性高血压患者分为CIMT增厚组(55例)和正常组(51例),比较两组铁蛋白、尿酸、Hcy、hs-CRP水平,采用logistic回归分析,并以ROC曲线评价CIMT增厚的预测价值。结果 增厚组的铁蛋白、尿酸、Hcy、hs-CRP水平均明显高于正常组(P<0.01)。logistic回归分析显示铁蛋白、尿酸、Hcy、hs-CRP均是CIMT增厚的独立危险因素(P<0.05)。铁蛋白、尿酸、Hcy、hs-CRP单独检测的AUC分别为0.735、0.802、0.818、0.778,4项指标联合检测的AUC为0.939(P<0.01)。结论 铁蛋白、尿酸、Hcy、hs-CRP在CIMT增厚预测中具有一定价值,但4种指标联合检测的预测效能最高。

    Abstract:

    Objective To investigate the predictive value of ferritin, uric acid, homocysteine (Hcy), and hypersensitive C-reactive protein (hs-CRP) for carotid intima-media thickening (CIMT) in primary hypertension. Methods A total of 106 patients with primary hypertension were divided into thickening group (55 cases) and normal group (51 cases). Ferritin, uric acid, Hcy, and hs-CRP levels were compared between 2 groups and analyzed Logistic regression analysis. Their predictive value for CIMT was evaluated using ROC curve. Results Ferritin, uric acid, Hcy, and hs-CRP levels were higher in thickening group than in normal group (P<0.01). Logistic regression analysis showed that they were independent risk factors for CIMT (P<0.05). The AUC of ferritin, uric acid, Hcy, hs-CRP, and their combination were 0.735, 0.802, 0.818, 0.778, and 0.939 (P<0.01), respectively. Conclusion There may be some predictive value of ferritin, uric acid, Hcy, and hs-CRP for CIMT in primary hypertension, with the highest of their combined detection.

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林梓波,陈华健,李立硕,等.铁蛋白、尿酸、同型半胱氨酸、超敏C反应蛋白对原发性高血压患者颈动脉内膜中层厚度增厚的预测价值[J].广东医科大学学报,2024,42(3):281-284.

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  • 在线发布日期: 2024-07-17
  • 出版日期: 2024-06-30

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