Abstract:Abstract: Objective To investigate the current situation and influencing factors of occupational stress and work fatigue in operating room nurses. Methods A total of 133 operating room nurses in three grade-A tertiary were surveyed using a CNSS and FS-14-based questionnaire. Results Among 133 operating room nurses, mild, moderate and severe stress was 6.8%, 67.7% and 25.6%, while mild, moderate and severe work fatigue was 30.8%, 42.9% and 26.3%, respectively. Logistic regression analysis revealed that work fatigue was the risk factor for occupational stress in operating room nurses(P<0.01). Conclusion The occupational stress and work fatigue can affect the working efficiency and service quality in operating room nurses.