Gustave Roussy Immune Score在消化系统恶性肿瘤患者预后评估中的研究进展

Research progress of Gustave Roussy Immune Score in prognosis assessment of patients with malignant tumors of digestive system

摘要:

摘 要：肿瘤的发生发展与机体的免疫状态、营养状态及肿瘤微环境息息相关，一些传统的评估方法对肿瘤的预后 评价效果已略显不足，这可能与它们仅基于肿瘤的形态学特征而未考虑机体免疫营养状态有关。近年，在对肿瘤预后评 估的领域出现了一种新的评分系统，即Gustave Roussy Immune Score（GRIm-Score）。该文通过梳理近年来应用该评分系 统的文献，回顾了该评分在常见消化系统恶性肿瘤患者预后评估中的应用，认为GRIm-Score是多种常见消化系统恶性肿 瘤预后的独立危险因素，高评分往往提示预后不良，且可能与免疫抑制剂治疗效果评估也有一定相关性。

Abstract:

Abstract: Tumor development and progression are closely related to the immune state, nutritional state, and tumor microenvironment. Traditional evaluation methods have been slightly insufficient in evaluating the prognosis of tumors, which mainly focus on the morphological characteristics of tumors instead of the immune nutritional state .Therefore, Gustave Roussy Immune Score (GRIm-Score), which is considered as new way to evaluate the tumor prognosis has been proposed in recent years. In this paper, we summarize recent application of this scoring system in prognosis assessment of patients with common digestive system malignant tumors and demonstrated that GRIm-Score is an independent risk factor for the prognosis of a variety of common digestive system malignancies, and high score often indicates poor prognosis, and may also have a certain correlation with the evaluation of immunosuppressive therapy effect.