A 74-year-old man with peripheral lung cancer underwent pulmonary wedge resection of left upper lobe and mediastinal lymph node resection. The patient was diagnosed as stage IIB (pT1bN1M0) pulmonary spindle cell carcinoma with adenocarcinoma. The genetic test revealed exon 19 deletion mutation of EGFR gene. The cancer was stable after EGFR-TKI targeted therapy