组蛋白赖氨酸甲基转移酶在急性髓系白血病中的研究进展

Advances on histone lysine methyltransferase in acute myeloid leukemia

摘要:

急性髓系白血病（AML）是一种源于造血干细胞的血液恶性肿瘤，具有治疗难度大、预后差等特点。表观遗 传学在白血病的发生、发展中起着重要作用。组蛋白甲基化修饰相关基因和酶作为AML治疗靶点的研究取得了较大进 展。该文就组蛋白H3 赖氨酸甲基转移酶在AML中的研究进展进行综述。

Abstract:

Acute myeloid leukemia (AML) is a hematologic malignancy derived from hematopoietic stem cells, with treatment difficulty and poor prognosis. Epigenetics plays an important role in the development and progression of leukemia. Histone methylation modification-associated genes and enzymes as therapeutic targets for AML have made great progress. This article briefly reviews the recent research progress of histone H3 lysine methyltransferase in AML.