蛋白质翻译后修饰在肝纤维化中的作用

Role of protein translational modifications in hepatic fibrosis

摘要:

肝纤维化（HF）由多种细胞、介质和信号通路调控，最终导致细胞外基质和胶原过度沉积的复杂病理过程。 蛋白质翻译后修饰（PTMs）是DNA转录成mRNA并进一步翻译成蛋白质后，底物与功能基团的一种化学修饰。HF的过 程经历了广泛的PTMs。该文就蛋白质磷酸化和亚硝基化修饰对HF的作用进行综述。

Abstract:

Hepatic fibrosis (HF) is complex pathological process that is regulated by a variety of cells, mediators, and signaling pathways, and leads to excessive deposition of extracellular matrix and collagens. Protein translational modifications (PTMs) are chemical modifications of substrates and functional groups after DNA is transcribed into mRNA and further translated into proteins. The HF process undergoes extensive PTMs. This paper reviews the role of protein phosphorylation and nitrosylation in HF.