糖尿病视网膜病变患者血清TNF-α的水平及意义

Significance of serum TNF-α levels in patients with diabetic retinopathy

摘要:

目的 分析糖尿病视网膜病变（DR）患者血清肿瘤坏死因子（TNF-α）水平及其意义。方法 检测 115 例 DR（DR组）、117 例 2 型糖尿病（DM组）、121 例单纯白内障（对照组）患者血清TNF-α和生化指标水平。结果 DR组和 DM组血清TNF-α水平高于对照组，其中DR组最高（P<0.01 或 0.05）。DR组血清TNF-α与肌酐、尿素氮、尿酸、收缩压呈 正相关，而与肾小球滤过率、高密度脂蛋白胆固醇呈负相关（P<0.01 或 0.05）。ROC曲线分析显示，TNF-α曲线下面积为 0.611。结论 DR患者血清TNF-α升高与肾损伤指标密切相关。

Abstract:

Objective To analyze the significance of serum TNF-α levels in patients with diabetic retinopathy (DR). Methods Serum levels of TNF-α and biochemical indexes were determined in 115 DR, 117 type 2 diabetes mellitus (DM), and 121 simple cataract (control group) patients. Results Serum TNF-α levels were higher in DR and DM groups than in control group, especially in DR group (P<0.05). In DR group, serum TNF-α concentrations were positively correlated with creatinine, blood urea nitrogen, uric acid, and systolic blood pressure, and negatively with eGFR and HDL-C (P<0.01 or 0.05). ROC curve analysis showed that the area under the curve of TNF-α was 0.611. Conclusion Serum TNF-α levels are associated with renal injury indicators in DR patients.