健康老年人左室射血分数与多种冠心病危险因素的相关性分析

Correlation between left ventricular ejection fraction and various risk factors for coronary heart disease in healthy elderly population

关键词:  左室射血分数  冠心病  危险因素  老年

Key words:  left ventricular ejection fraction  coronary heart disease  risk factors  elderly population

摘要:

目的　 探讨老年人左室射血分数（LVEF）水平与多种冠心病危险因素的相关性。方法　324 例心脏多 普勒超声测定均未发现明确的器质性心脏疾病的老年人根据 LVEF 值，将 LVEF<50% 者设为 LVEF 下降组（n=130）， LVEF≥50%者设为LVEF正常组（n=194）。比较两组吸烟史、肥胖、低密度脂蛋白胆固醇（LDL-C）、高血压病和 2 型糖 尿病等冠心病危险因素数据，应用皮尔逊线性相关、多因素Logistic回归分析评估LVEF与以上危险因素的相关性。结果　 皮尔逊线性相关分析显示LVEF与LDL-C水平呈负相关（r=-0.336，P<0.001）。多因素logistic回归分析发现吸烟史、肥 胖、LDL-C高水平与LVEF降低存在显著相关性（P<0.001 或 0.05）。结论　老年人LVEF下降与吸烟史、肥胖和LDL-C 升高有关。

Abstract:

Objective　To investigate the correlation between left ventricular ejection fraction (LVEF) and multiple risk factors for coronary heart disease (CHD) in elderly population. Methods　According to 50% cutoff of LVEF value, 324 elderly subjects without structural heart disease using echocardiography were divided into normal (n=194) and low (n=130) LVEF groups. The correlation between LVEF and CHD risk factors including smoking, obesity, low-density lipoprotein cholesterol (LDL-C), hypertension and type 2 diabetes were analyzed by Pearson linear correlation and multivariate logistic regression in both groups. Results　Pearson linear correlation analysis showed a negative correlation between LVEF and LDL-C level (r=-0.336, P<0.001). Multivariate logistic regression analysis revealed that smoking, obesity and high LDL-C level were significantly correlated with low LVEF (P<0.001 or 0.05). Conclusion　Low LVEF is associated with smoking, obesity and elevated LDL-C in the elderly.