Abstract:Objective To analyze the risk factors for vulnerable COVID-19 patients. Methods Clinical data of 201 vulnerable COVID-19 patients aged 60 years or more were used to analyze the risk factors for hospitalization mortality. Results There were 158 survivals (78.6%) and 43 deaths (21.4%) of 201 cases. Logistic regression analysis showed C-reactive protein (CRP), ground-glass opacity (GGO), triglycerides, platelet/lymphocyte ratio (PLR), triglyceride-glucose index (TyG), and platelets were independent factors for hospital mortality (P<0.05). The area under the curve (AUC), specificity and sensitivity of triglycerides + CRP + GGO + platelets + PLR + TyG were 0.914 (95% CI: 0.869-0.960, P<0.001), 0.744, 0.943, respectively for hospital mortality. Conclusion The high hospital mortality of vulnerable COVID-19 patients is associated with triglycerides, TyG, GGO, CRP, PLR, and platelets.