| 摘要: |
| 细菌生物膜（BF）是细菌在物体表面形成的一种复杂三维结构，具有高度耐药性和环境适应性。BF的形成是
细菌适应环境和导致持续感染的重要方式，其存在严重威胁人类健康。细菌磷酸转移酶系统（PTS）作为细菌糖类摄取和代
谢糖类的关键系统，在细菌代谢和信号传导中发挥至关重要的作用，其通过独特的磷酸化级联反应，从而精确调控糖类的运
输和代谢，进而影响细菌的生理状态和行为模式。该文就PTS关键组分在不同细菌中对其BF影响的研究进展作一综述。 |
| 关键词: 关键词：磷酸转移酶系统 细菌 生物膜 糖代谢 |
| DOI： |
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| 基金项目:国家自然科学基金（82301752），广东省自然科学基金（2018A0303070018），广东省医学科学技术研究基金项目（A2021207）， 广东省普通高校特色创新项目（2020KJSCX041） |
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| Advances in the study of the bacterial phosphotransferase system affecting bacterial biofilms by regulating sugar metabolism |
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| Abstract: |
| Bacterial biofilm (BF) is a complex three-dimensional structure formed by bacteria on the surface of an object
that is highly resistant to drugs and environmentally adapted.The formation of BF is an important way for bacteria to adapt
to the environment and lead to persistent infections, and its presence poses a serious threat to human health. The bacterial
phosphotransferase system (PTS), a key system for bacterial sugar uptake and metabolism of sugars, plays a crucial role in
bacterial metabolism and signaling through a unique phosphorylation cascade reaction PTS precisely regulating sugar transport
and metabolism, which in turn affects bacterial physiological states and behavioral patterns. This article provides a review of the
progress of research on the effects of key components of PTS on its BF in different bacteria. |
| Key words: phosphotransferase system bacteria biofilm sugar metabolism |