多导睡眠监测在多系统萎缩伴睡眠障碍患者中的应用

Application of polysomnography in patients with multiple system atrophy and somnipathy

摘要:

摘 要：目的 利用多导睡眠监测（PSG）分析多系统萎缩（MSA）患者的睡眠障碍。方法 6 例MSA患者和 6 例对 照者进行PSG监测，比较两组总睡眠时间、睡眠效率、睡眠潜伏期、入睡后清醒时间、觉醒次数、各睡眠分期占比、微觉醒 指数、呼吸暂停低通气指数（AHI）、睡眠周期性肢体运动指数（PLMSI）等指标。结果 MSA患者总睡眠时间和睡眠效率 低于对照组（P<0.01）；入睡后清醒时间、浅睡眠N1 期比例、微觉醒指数、AHI、PLMSI均高于对照组（P<0.01 或 0.05）。 5 例MSA患者出现快动眼睡眠肌张力失迟缓（RSWA），4 例出现喘鸣，2 例出现大喊大叫及拳打脚踢现象。结论 MSA 患者存在较严重睡眠障碍。

关键词:多系统萎缩;睡眠障碍;多导睡眠监测

Abstract:

Abstract: Objective To study the somnipathy in patients with multiple system atrophy (MSA) using polysomnography (PSG). Methods Six MSA patients and 6 healthy controls underwent PSG. Total sleep time, sleep efficiency, sleep latency, wake after sleep onset (WASO), awaking times, sleep stages, microarousal index, apnea-hypopnea index (AHI), and periodic limb movement of sleep index (PLMSI) were compared between two groups. Results Compared with control group, total sleep time and sleep efficiency were lower (P<0.01), while WASO, N1 light sleep, microarousal index, AHI, and PLMSI were higher in control group (P<0.01 or 0.05). In addition, REM sleep dystonia, stridor and disturbed episodes occurred in 5, 4 and 2 MSA patients. Conclusion There is a severe somnipathy in MSA patients.

Key words:multiple system atrophy; somnipathy; polysomnography