老年人小腿围、HCAR与认知障碍的因果中介分析——基于CLHLS2014数据

Causal mediation analysis of Calf Circumference, HCAR and Cognitive Impairment in older adults-based on CLHLS2014 data

关键词:  超敏C反应蛋白/白蛋白比值  小腿围  认知障碍  中介分析  CLHLS数据库

Key words:  high-sensitivity C-reactive protein (hs-CRP)/albumin ratio (HCAR)  calf circumference  cognitive impairment  Mediation analysis  Chinese longitudinal healthy longevity survey(CLHLS) database

摘要:

摘　 要：目的　 探究小腿围与认知障碍的关系及超敏C反应蛋白/白蛋白比值(hypersensitive C-reactive protein/ albumin ratio, HCAR)的中介作用。方法　筛选 2014 年CLHLS数据库中的 1 784 例老年人数据。通过中文版简易精神 状态量表(Chinese version of the brief mental state examination, cMMSE)评估认知功能。使用R软件进行数据处理和分 析，Bootstrap抽样法验证中介效应。结果　校正多种协变量后，小腿围与认知障碍呈显著负相关(OR= 0.951，95% CI： 0.933~0.970)，HCAR在其中起到中介作用(中介效应比例为 0.022，95%CI：0.002~0.060)。结论　小腿围与认知障碍之 间存在负关联，HCAR起中介作用。该发现对预防和干预认知障碍有重要意义。

Abstract:

Abstract: Objective This study aims to investigate the relationship between calf circumference and cognitive impairment and to study the mediating role of the hypersensitive C-reactive protein (hs-CRP)/albumin ratio (HCAR). Methods Data in the 2014 CLHLS database were analyzed, and 1 784 study participants were finally included in this study. Cognitive function was assessed by the Chinese version of the brief mental state examination (cMMSE). Data were processed and analysed using R software, and mediating effects were verified using Bootstrap sampling. Results After correcting for multiple factors, calf circumference was significantly negatively associated with cognitive impairment (OR= 0.951, 95% CI: 0.933-0.970), in which HCAR played a mediating role (mediating effect ratio 0.022, 95% CI: 0.002-0.060). Conclusion There is a negative association between calf circumference and cognitive impairment, in with HCAR plays a mediating role. This finding has important implications for the prevention and intervention of cognitive impairment.