| 摘要: |
| 摘 要：线粒体是三羧酸循环的主要场所，几乎是所有真核细胞的能量供应站。衰
老伴随着线粒体功能的丧失和损伤线粒体的累积。线粒体自噬是细胞清除衰老损伤线
粒体的主要机制。细胞内的线粒体自噬不足，损伤线粒体的累积可以作为细胞衰老的
标志物。因此，研究线粒体自噬的机制、调控途径以及寻找干预线粒体自噬的策略，对于延缓衰老具有重要意义。该文阐
述了线粒体自噬与衰老相关的分子调控网络以及干预线粒体自噬延缓衰老的策略及研究方向，旨在推进靶向线粒体自
噬治疗衰老相关疾病的发展。 |
| 关键词: 线粒体自噬 衰老 自噬 抗衰老 信号通路 |
| DOI： |
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| 基金项目:国家自然科学基金项目（82172502,81974127） |
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| Mitophagy and aging |
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| Abstract: |
| Abstract: Mitochondria is the central hub of the tricarboxylic acid cycle and plays a crucial role in generating cellular
energy and as the primary energy providers for almost all eukaryotic cells. The aging process is characterized by a decline in
mitochondrial function and the accumulation of damaged mitochondria. Mitophagy serves as the primary mechanism through
which cells eliminate aging-related damaged mitochondria. Inadequate mitochondrial autophagy and the accumulation of
damaged mitochondria can be indicative of the aging process. Therefore, investigating the mechanisms and regulatory pathways
of mitophagy and identifying strategies to modulate this process are of paramount importance in delaying the aging process.
This review provides a comprehensive overview of the molecular regulatory networks connecting mitophagy and aging, as well
as discusses strategies to manipulate mitophagy for the purpose of delaying the aging process. Additionally, this review explores
future prospects in this field. The aim is to advance the development of targeted mitochondrial autophagy for the treatment of
age-related diseases. |
| Key words: mitophagy aging autophagy anti-aging signaling pathway |