糖化血红蛋白、同型半胱氨酸与中老年急性冠脉综合征患者冠脉病变相关性分析

Correlation between glycosylated hemoglobin, homocysteine and coronary artery lesions in middle-aged and elderly patients with acute coronary syndrome

关键词:  糖化血红蛋白  同型半胱氨酸  急性冠脉综合征

Key words:  glycosylated hemoglobin  homocysteine  acute coronary syndrome

摘要:

目的　了解糖化血红蛋白（HbA1c）、同型半胱氨酸（Hcy）与急性冠脉综合征（ACS）患者冠脉病变相关性。方 法　515 例中老年ACS患者根据冠脉造影结果分为单支冠脉病变组和多支冠脉病变组，根据Gensini评分分为轻度和中重 度病变组，采用Pearson相关性分析HbA1c、Hcy与冠脉病变相关性。结果　单支、轻度病变组HbA1c、Hcy水平低于多支、 中重度病变组（P<0.01 或 0.05）。HbA1c水平与多支病变存在正相关（r=0.103，P<0.05），而Hcy水平与病变严重程度存在 正相关（r=0.164，P<0.01）。结论　高水平HbA1c、Hcy分别与中老年ACS患者冠脉多支、中重度冠脉病变发生有关。

Abstract:

Objective　To investigate the correlation between glycosylated hemoglobin (HbA1c), homocysteine (Hcy) and coronary artery lesions in middle-aged and elderly patients with acute coronary syndrome (ACS). Methods　A total of 515 middle-aged and elderly patients with ACS were divided into single-vessel and multi-vessel groups according to coronary angiography, and mild and moderate/severe groups based on Gensini scores. The correlation between HbA1c, Hcy and coronary artery lesions was evaluated by Pearson correlation analysis. Results　HbA1c and Hcy levels were lower in single-vessel and mild ACS groups than in multi-vessel and moderate/severe ACS groups (P<0.01 or 0.05). There were positive correlations between HbA1c and multi-vessel lesions (r=0.103, P<0.05) and between Hcy and moderate/severe ACS (r=0.164, P<0.01). Conclusion　HbA1c and Hcy could be respectively contribute to multi-vessel lesions and moderate/severe ACS in middle- aged and elderly patients.